2. Apoptosis
  3. Apoptosis
  4. Tafasitamab

Tafasitamab  (Synonyms: 坦昔妥单抗; XmAb5574; MOR00208; Tafasitamab-cxix)

目录号: HY-P9981 纯度: 98.53%
COA

摩尔计算器

Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体，可与人 B 细胞表面抗原 CD19 结合。

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CAS No. : 1422527-84-1

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1 mg ￥4000
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5 mg ￥10500
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Customer Review

Tafasitamab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Tafasitamab (XmAb5574) 以 E/T 比率依赖性方式诱导对 Mino 和 Jeko (MCL) 细胞系的细胞毒性。Tafasitamab (XmAb5574) 增加 ADCP 和抗增殖活性。Tafasitamab (XmAb5574) 可增强半胱天冬酶诱导细胞凋亡引起的抗增殖细胞凋亡活性[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tafasitamab 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: NHL cell lines and primary CLL and MCL cells by γδ T cells
Concentration:
Incubation Time: 2 h
Result: Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells.

Cell Proliferation Assay[2]

Cell Line: SU-DHL-6 cells
Concentration:
Incubation Time: 72 h
Result: Showed potent antiproliferative effects on tumor cell.

Apoptosis Analysis[2]

Cell Line: SU-DHL-6 cells
Concentration: 0-4 ng/mL
Incubation Time: 48 h
Result: Showed potent antiproliferative effects due to caspase-induced apoptosis
体内研究
(In Vivo)

Tafasitamab (XmAb5574) 以 E/T 比率依赖性方式诱导对 Mino 和 Jeko (MCL) 细胞系的细胞毒性。Tafasitamab (XmAb5574) 增加 ADCP 和抗增殖活性。Tafasitamab (XmAb5574) 可增强半胱天冬酶诱导细胞凋亡引起的抗增殖细胞凋亡活性[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Disseminated Raji model[1].
Dosage: 2.5 μg/kg
Administration: Tafasitamab (SC, once on Day 1, 2.5 μg/kg)
Result: Showed antitumor activity in disseminated Raji model.
Animal Model: Disseminated Ramos model[1].
Dosage: 10 mg/kg
Administration: Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of 10 mg/kg)
Result: Showed antitumor activity in disseminated Ramos model.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

坦昔妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-G2-kappa
Biological Activity
  • Tafasitamab has a significant ADCP effect on Raji cells in a dose-dependent manner.The EC50 for this effect is 95.42 and 117.87 ng/mL.
纯度 & 产品资料

纯度: 98.53%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tafasitamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tafasitamab1422527-84-1XmAb5574 MOR00208 Tafasitamab-cxix坦昔妥单抗XmAb 5574XmAb-5574MOR00208MOR 00208MOR-00208ApoptosisCD19 antibodyb-cellimmunotherapyInhibitorinhibitorinhibit

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